AIM:To investigate fundus changes in patients infected by human immunodeficiency virus.METHODS:The study included 120 cases with an HIV infection that underwent ophthalmologic examinations.None of the patients has any systemic opportunistic infection and other system diseases found.The CD4+ T lymphocyte counts were no less than 200×106/L.They didn’t undergo highly active antiretroviral therapy.RESULTS:In all the 120 patients,the visual acuity in 114 cases(95%)of 221 eyes(92.1%) were no less than 1.0.Three cases (2.5%) of 4 eyes (1.7%) were found point and sheet bleeding in retinal posterior pole.1 case (0.8%)of 1 eye was found cotton-wool spots in the posterior pole.Retinal microvascular abnormalities were found in 4 cases (3.3%).CONCLUSION:Retinal microvasculopathy is the early fundus changes of the patients infected by the immunodeficiency virus.It happened seldom when the CD4+ T lymphocyte counts were no less than 200×106/L,and without significant effect on visual acuity.