AIM:To compare the efficacy of Q-switching Nd:YAG laser and operation peripheral iridotomy.METHODS:The retrospective analysis involved 108 eyes of laser group and 78 eyes of surgery group,the intraocular pressure,vision,anterior chamber depth,operative complications were observed after operation.RESULTS:Six months after operation,the intraocular pressure control rate of two groups had no difference.The improvement of visual acuity of two groups had significant difference.The laser group are superior to surgery group(P<0.05).CONCLUSION:Q-switching Nd:YAG laser peripheral iridotomy can be handled easily,which is a safe and effective method for treatment of glaucoma,but cannot completely substitute the surgery of peripheral iridotomy.