AIM:To observe clinical effect of Methycobal combined with Fufang Xueshuantong capsule and Vitaminum B1 in treatment on diabetic ophthalmoplegia.METHODS:In recent four years,64 cases were asked to take orally Methycobal combined with Fufang Xueshuantong capsule and VitaminumB1 in treatment of diabetic ophthalmoplegia on foundation of treatment on diabetes.Fufang Xueshuantong capsule and VitaminumB1 treatment were established as control group.RESULTS:After 2-16 weeks of treatment,symptoms of two groups disappeared or relieved inordinately.After 3 months of treatment,the efficacies of treatment with Methycobal combined with Fufang Xueshuantong capsule and VitaminumB1 were superior to the control group.CONCLUSION:Methycobal combined with Fufang Xueshuantong capsule and VitaminumB1 is effective and safe in the treatment for acute diabetic ophthalmoplegia.