AIM: To investigate the mechanism of shijueming prevention and cure on cataract METHODS: Eighty rats were randomly divided into 4 groups,with 20 in each group.Ten animals in group A were taken as health control,the other animals in group B、C and D were made as D-galactose cataract models.Group A and group B were dropped with saline eyedrops;Group C was dropped with pirenoxine sodium eyedrops;Group D was dropped with extract liquid from shijueming.Then,the animals’ pupils were dilated and lens changes were observed under the slit-lamp and taken photograph at 5th,10th,15th day.At the 15th day all animals were killed,the content of SOD,GSH and GSH-PX from lens were measured·RESULTS: The content of SOD,GSH and GSH-PX was significantly higher in the group A than that in group B,C and D(P<0.01);The content of SOD,GSH and GSH-PX was significantly higher in the group D than that in group B(P<0.05).The degree of lens opacity in rats: compared with group B,group D had significantly lighter lens opacities and slower development,also slightly better than group C·CONCLUSION: Shijueming can effectively improve the antioxidant capacity of the lens,and protect the lens against cataract development.