AIM:To analyze the effect of corneal ulcer debridement combined with antimycotic drug for fungal keratitis·METHODS:Collecting 2010-09/ 2011-09 fungal keratitis 30 cases in our hospital,all patients were treated with corneal scraping,followed with corneal ulcer debridement,and fluconazole or natamycin eyedrop according to the severity of keratitis,ineffective treatment cases resorted to the self conjunctiva cover or lamellar kemtoplasty.The therapetic results were observed with following up·RESULTS:Totally 27 cases corneal blade and fungi culture were positive,positive rate were 90%.Among these cases,6 mild keratitis cases all recovered after corneal ulcer debridement combined with fluconazole eyedrop,course 2-3weeks.The moderate keratitis were 17 cases,12 cases recovered after corneal ulcer debridement combined with natamycin eyedrop,course 4-10weeks.7 cases became serious,among which 3 cases underwent self conjunctiva cover,1 cases underwent the lamellar kemtoplasty.The total effective rate of corneal ulcer debridement combining with antimycotic drug for fungal keratitis was 70%·CONCLUSION:Corneal ulceration debridement combined with antimycotic drug is simple,economic,effective and feasible treatment for fungal keratitis.