AIM:To evaluate the effectiveness of pneumatic retinopexy(PR) with cryopexy in the therapy of inferior rhegmatogenous retinal detachment(RRD)·METHODS:Twenty-two patients(22 eyes) were included in this study.The RRD diagnosis was confirmed by best-corrected visual acuity(BCVA),slit-lamp microscope,indirect ophthalmoscope and Goldman three-mirror contact lens.All patients had undergone PR with cryopexy,and the post-operative follow-up was 6 to 24 months with an average of 12 months.Post-operative BCVA and final anatomical outcome was analyzed·RESULTS:The reattachment rate of single PR was 77%(17/22 eyes),and 2 eyes required additional intravitreal injection of the gas.The total reattachment rate of PR was 86%(19/22 eyes).Three eyes needed additional scleral buckling.Final retinal reattachment was achieved in all 22 subjects(100%).Postoperative BCVA was significantly improved(P<0.01)·CONCLUSION:PR is an effective surgery for inferior RRD·