AIM:To evaluate the efficacy and safety of Pranoprofen eye drops in relieving reactions of postoperative inflammation of Nd:YAG laser to treat the disease of the anterior segment of the eye·METHODS:Totally 60 cases(60 eyes) with angle-closed glaucoma were performed laser peripheral iridotomy(LPI) and laser capsulotomy,then were randomly divided into two groups,experimental group and control group,30 cases(30 eyes) of each group.Pranoprofen and TobraDex eye drops,four times each day,were administered in experimental and control group respectively.All patients had been observed for 7 days.Ocular pain,photophobia,epiphora,conjunctival congestion,keratitis,aqueous humor flare were observed and recorded to calculate a comprehensive score to assess the curative effects·RESULTS:There was no significant difference in comprehensive score between the two groups at 1 day,3,7 days postoperatively(P>0.05)·CONCLUSION:Pranoprofen eye drops have excellent efficacy and safety to control the inflammation after laser peripheral iridotomy and laser capsulotomy,it can decrease the danger of high intraocular pressure due to corticosteroid.