AIM:To analyse the efficiency of nonpenetrating trabeculectomy(NPT) combined with hyaluronic acid biologic glue implantation and mitomycin C(MMC) usage in the treatment of open angle glaucoma·METHODS: A retrospective analysis was made of 20 cases(24 eyes) with open angle glaucoma which had undergone NPT combined with hyaluronic acid biologic glue implantation and MMC usage under the layer of scleral valve.All the cases were followed up for 12-36 months.The intraocular pressure(IOP),visual acuity,anterior chamber depth,and filtering bleb were observed·RESULTS:The IOP was decreased from 35.52±7.6mmHg preoperatively to 16.32±5.25,17.28±5.70,18.26±5.20mmHg postoperatively in 1 year;2,3 years respectively(P<0.01).Visual acuity was at or above the preoperative level in 22 eyes,vision decreased in 2 eyes.There were no intraoperative or postoperative shallow anterior chamber and anterior chamber inflammation.All 24 eyes had functional bleb·CONCLUSION:NPT combined with hyaluronic acid biologic glue implantation and MMC usage is safe and effective in the management of open angle glaucoma.