AIM:To evaluate the efficacy of deproteinized calfblood extract eye gel for dry eye by observing changes in the patientˊs subjective symptoms and laboratory test results of dry eye before and after treatment. METHODS:Totally 22 selected cases of 43 dry eyes were treated with deproteinized calfblood extract eye gel 3 times/d.Patients were observed with subjective symptoms: dryness, foreign body sensation, burning sensation, visual fatigue, redness, pain, photophobia, lacrimation; and dry eye laboratory tests: fluorescein staining, tear film break-up time(BUT), SchirmerⅠtest (SⅠt) on the day of treatment and 1 week,2 weeks,1 month after medication. RESULTS:One month after medication, the patient’s subjective symptoms gradings were significantly different with those before treatment (P<0.01), the 8 subjective symptoms were visibly relieved; after treatment, the patientˊs fluorescein staining, BUT and SⅠt values were significantly different with those before treatment (P<0.01). CONCLUSION: Deproteinized calfblood extract eye gel is effective for treatment of dry eye.