AIM:To observe the curative effect of Ziyinrunmu pill, which is composed by medicine compatibility method of nourishing liver and kidney and promoting the secretion of saliva and moistening dryness on dry eye syndrome. METHODS:All 40 cases in treatment group were treated with oral Ziyinrunmu pill on the basis of routine western medicine ( tears Naturale eye drops and 3g/L tobramycin eye drops )treatment,40 cases in control group with routine western medicine (tears Naturale eye drops and 3g/L tobramycin eye drops). RESULTS:The total effective rate was 82% in treatment group and 45% in control group. CONCLUSION: Ziyinrunmu pill has good curative effect for the treatment of dry eye syndrome.