目的：探讨高眼压的致病因素、演变过程与开角型青光眼的关系及药物治疗。 方法：对217例高眼压症患者进行10a以内的随访。包括对眼压、视野、视盘、RNFL以及伴有全身性疾病因素的检查。 结果：随访中181例眼压维持原状或无明显变化，27例眼压增高，9例视野出现缺陷。 结论：高眼压与开角型青光眼不是一种病，但高眼压合并的各种不利因素可使高眼压过渡到开角型青光眼。因此应密切随访观察，必要时积极进行抗青光眼治疗。

AIM:To study the pathogenic factors of high intraocular pressure, evolution process and relation with open angle glaucoma, and drug therapy. METHODS:Totally 217 cases of patients with ocular hypertension had 10 years follow-up including intraocular pressure, optic disc, vision, RNFL and accompanied by systemic disease factors examined. RESULTS: In the follow-up intraocular pressure of 181 cases maintained the status or no significant change, intraocular pressure elevated in 27 cases, visual field defects occurred in 9 patients . CONCLUSION: High intraocular pressure,and open angle glaucoma are not the same disease, but high intraocular pressure with the adverse factors can make the transition to high intraocular pressure in primary open angle glaucoma. So it should be followed up and observed closely, when necessary, anti-glaucoma treatment should be actively carried out.