目的：探讨双重黏弹剂DisCoVisc和单纯Healon在白内障超声乳化摘除及折叠人工晶状体植入术中对角膜内皮的保护作用。 方法：将60例60眼单纯性硬核（≥Ⅳ级核）白内障分两组，每组30例30眼。第一组操作中应用双重DisCoVisc作为观察组；第二组操作中应用单纯Healon作为对照组。观察术后1d角膜水肿情况,术前及术后1mo角膜内皮细胞计数。 结果：观察组和对照组术后角膜水肿差异有统计学意义(P<0.01),术前、术后1mo角膜内皮丢失率无统计学意义(P>0.05)。 结论：硬核白内障超声乳化术中应用双重黏弹剂DisCoVisc较单纯Healon可以更有效保护角膜内皮细胞，减少术后角膜水肿,提高手术的安全性。

To explore the bilviscoelastic materials DisCoVisc and Healon alone on the protection of corneal endothelium in cataract phacoemulsification and foldable intraocular lens implantation. METHODS: Totally 60 cases (60 eyes ) of simple hard nuclear (≥IV nucleus) cataract were divided into two groups, each of 30 cases ( 30 eyes). The first group used bilviscoelastic materials DisCoVisc as observation group; the second group used Healon alone as control group. Observation was conducted on corneal edema of postoperative 1 day , and corneal endothelial cell count of preoperative and postoperative 1 month . RESULTS:The observation group and the control group had a significant difference in the postoperative corneal edema (P<0.01 ) and no difference of statistical significance in corneal endothelial cell loss rate of preoperative and postoperative 1 month (P>0.05 ). CONCLUSION: The application of bilviscoelastic materials DisCoVisc in phacoemulsification of hard nuclear cataract can more effectively protect the corneal endothelium than Healon, reduce postoperative corneal edema, and improve operation safety.