Abstract:To demonstrate the effect of Ahmed glaucoma valve implantation and intravitreal avastin in the treatment of neovascular glaucoma(NVG). METHODS:A retrospective random case series study was performed. Twenty eyes of-twenty cases who presented with NVG were first treated with intravitreal bevacizumab 2.5 mg in 0.1 mL,then with Ahmed glaucoma valve implantation after regression of iris neovessels. Cases were followed up for 6-36(mean 24) months with observation on visual acuity, IOP control, regression of iris neovessels, and complications during or after surgery. RESULTS:All cases regressed iris neovessels at different degree within 1 week after injection. At final follow-up, the IOP of 16 eyes were all less than 21mmHg without any drugs and of 3 eyes with 1-3 kinds of anti-glaucoma drugs after combined Ahmed glaucoma valve implantation. The IOP of one eye was controlled after cryotherapy. The mean IOP dropped from 44.17±1617mmHg preoperatively to 13.62±3.81mmHg postoperatively. IOP reduction was statistically different between preoperative and postoperative (t=11.028,P=0000) at final follow-up.Visual acuity was improved in 8 cases (40%) and was no changed in 12 cases.No serious complications were observed during or after intravitreous injection and Ahmed glaucoma valve implantation. CONCLUSION:Ahmed glaucoma valve implantation and intravitreal avastin in the treatment of NVG is useful and safe. On one hand, it improves the success rate of surgery and preserves visual function,furthermore its complications are less. However, its chronic effect needs to further follow-up. At the same time, we should take some treatment to the protopathy of this disease.