AIM:To observe the clinical effect of microperimetry-1 (MP-1) combined microperimetry in detection of early diagnosis in acute retrobulbar neuritis.METHODS: Standard W-WP and MP-1 were used respectively on the physical examination of normal youth in 20 cases (40 eyes), 45 cases of acute retrobulbar neuritis (62 eyes) testing. RESULTS: The difference of mean sensitivity(MS) of the MP-1 detection between the two groups was 10.3 ± 1.10dB, and mean defect(MD) of visual field ofMP-1 detection; between the two groups was -2.5±3.23dB, which was with significant statistically differenct (P<0.01); the detection sensitivity of MP-1 on visual function damage in acute retrobulbar was higher than standard W-WP, specific to 90%, sensitive 92%. CONCLUSION: MP-1 has an intuitive basis of unique objective retinal anatomy and subjective quantitative highly sensitive of visual pinpoint of visual function damage than standard W-WP it has unique effect in early clinical diagnosis, treatment and follow-up of acute retrobulbar neuritis, shows that.