AIM:To evaluate the influence of wearing soft contact lens(SCL) on central corneal thickness(CCT) and curvature.METHODS：The CCT and corneal topography of 143 cases (286 eyes) who were wearing SCL were measured with ultrasonic pachymeter. 154 normal subjects were selected as control. The difference of CCT and corneal curvature among normal subjects and subjects wearing SCL in different duration were analyzed.RESULTS：There was no statistically significant difference in CCT between short-term wearing patients(≤2 years) and the control. CCT of long-term wearing patients(>2 years) was significantly thinner than CCT of the control and the patients worn SCL short term(<2 years) (P<0.05). There was no significant difference among all groups in corneal curvature(P<0.05).CONCLUSION: CCT did not change in short term wearing eyes. However, CCT decreased gradually with time passing in long term of contact lens wear. There was no relation between corneal curvature and the time of contact lens wear. Corneal unregularity was inclined to increase with long-term wear of contact lenses.