AIM:To compare the change of corneal endothelial cell density (ECD) and topography parameters after cataract phacoemulsification in eyes after antiglaucoma surgery and normal eyes.METHODS:Form January 2010 to December 2010, 200 eyes after phacoemulsification were divided into experimental group (after glaucoma surgery group) and control group (normal eye group) with 100 in each group. The ECD and topography parameters, including central corneal thickness (CCT) and corneal volume(CV), were examined preoperatively and 1 month and 3 months after surgery.RESULTS:Preoperatively, the mean ECD inexperimental group(1203±245/mm²) was significantly lower than that in control group(2648±167/mm², P<0.01), and the CCT and CV in experimental group(543±32μm and 59.14±2.79mm³) were significantly greater than those in control group(525±36μm and 57.26±3.24mm³; P<0.01, P＜0.05, respectively). One month and 3 months postoperatively, the mean ECD was significantly less while the CCT and CV were significantly greater in experimental group than those in control group(P＜0.01). However, no significant difference in the percentage of cell loss was found between groups at 1 or 3 months(P=0.1145, P=0.2018, respectively). The percentage increase in CCT and CV was significantly greater in experimental group than control group in 1 month(P=0.0142, P=0.0134, respectively), although there was no significant difference at 3 months(P=0.3562,P=0.4538, respectively).CONCLUSION:More sophisticated surgery and more refined surgical procedures are needed to minimize the damage to endothelial cells, and shorten the recovery time of corneal edema, and reduce the risk of corneal endothelial decompensation in cataract eyes after antiglaucoma surgery.