低剂量PDT治疗中心性浆液性脉络膜视网膜病变
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Efficacy of photodynamic therapy with 1/2 dose verteporfin for treating central serous chorioretinopathy
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    摘要:

    目的:观察低剂量光动力学疗法(photodynamic therapy, PDT)治疗中心性浆液性脉络膜视网膜病变(central serous chorioretinopathy, CSC)的短期疗效。

    方法:选取急性CSC患者36例36眼,进行单次1/2量维替泊芬(3mg/m2)进行PDT治疗,分别于术前和术后1,4,12,24wk进行最佳矫正视力和OCT的检查,术前、术后4,24wk进行FFA和ICG检查。

    结果:术后1wk,36眼中有27眼(75%)OCT显示视网膜下积液完全吸收,其余9眼(25%)视网膜下液部分吸收; 术后4wk,36眼视网膜下积液全部吸收,FFA+ICG示36眼荧光渗漏完全消失,脉络膜血管高渗透性消失; 术后12~24wk,36眼无复发。治疗后4wk,最佳矫正视力从术前平均0.52提高至0.80。随访期间36眼未见任何不良反应。

    结论:低剂量PDT治疗CSC短期内安全有效,能缩短病程,显著提高视力。

    Abstract:

    AIM:To evaluate the efficacy of photodynamic therapy(PDT)after 1/2 dose verteporfin injection in treating central serous chorioretinopathy(CSC).

    METHODS:Thirty-six eyes of 36 patients diagnosed with CSC received one single session of PDT using 1/2 dose(3mg/m2)verteporfin. Best-corrected visual acuity(BCVA)and OCT were measured before, 1 week, 4, 12 and 24 weeks after PDT treatment with 1/2 dose. OCT, FFA and ICG examination were performed before, 4 and 24 weeks after PDT treatment with 1/2 dose.

    RESULTS:Twenty-seven of 36 eyes(75%)had complete resolution of subretinal fluid(SRF)1 week after 1/2 dose PDT treatment. SRF was partly absorbed in 9 of 36 eyes(25%). After 4 weeks, SRF in 36 eyes was completely absorbed, fluorescein leakage of 36 eyes disappeared in FFA and the tortuous choroidal vessels appeared normal in ICG; Twelve to twenty-four weeks after PDT treatment, there was no recurrence of CSC in 36 eyes. The mean BCVA was improved from 0.52 to 0.80 four weeks after PDT treatment.

    CONCLUSION:PDT with 1/2 dose verteporfin injection is effective and safe in treating CSC in short time follow-up. It can shorten the coursing of CSC and protect the macular visual function.

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庄晓彤,肖伟.低剂量PDT治疗中心性浆液性脉络膜视网膜病变.国际眼科杂志, 2012,12(12):2368-2370.

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  • 收稿日期:2012-07-13
  • 最后修改日期:2012-11-20
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