AIM: To investigate the safety and efficacy of trabeculectomy in glaucoma and ocular hypertension status.

METHODS:For 25 glaucoma patients 26 eyes whose intraocular pressure was still abnormal after full antihypertensive treatment, the anterior chamber puncture was performed to release aqueous, then the patients underwent the trabeculectomy, the efficacy and complications were observed.

RESULTS: All operations were successfully completed,without choroidal hemorrhage, vitreous loss or other serious complications, postoperative intraocular pressure was ≤21mmHg, and postoperative visual acuity improved in 25 eyes, the total efficiency was 96.2%.

CONCLUSION:Treatment of glaucoma with trabeculectomy is safe, simple, and reliable. And for the glaucoma with uncontrolled persistent ocular hypertension, release of aqueous and then trabeculectomy is still the most effective, ideal technique.