AIM: To report the effects of subthreshold transpupillary thermotherapy(TTT)on the subsequent serous neurosensory detachment of chronic central serous chorioretinopathy(CCSC).

METHODS: Thirteen eyes of 10 CCSC patients who have been suffered serous neurosensory detachment for at least six months were treated with subthreshold TTT by using 810nm diode laser. Lesion changes have been compared via ophthalmic examination, angiography and OCT. The comparative study of the best corrected visual acuity(BCVA)was conducted under self-control method.

RESULTS: The average treatment of each patient by TTT was(1.23±0.44). All patients were followed up for 6 months. Before treatment, visual acuity was 0.05-0.4(0.16±0.10), and after treatment the vision was 0.05-0.8(0.35±0.21). The difference of visual acuity was statistically significant(P<0.05). No leakage of fluorescent dyes of FFA after treatment. No obvious choroidal permeability increase was noticed. The treatment-related side effects were not found in the treatment area.

CONCLUSION: The subthreshold TTT has obvious therapeutic effect on sustained neural epithelium detachment CCSC while there is no significant complications.