AIM: To investigate patients who suffering bullous keratopathy, postoperative pterygium and filamentary keratopathy, by wearing hydrophilic soft corneal contact lens at the same time, and observe the treatment effect on alleviating corneal irritation symptoms and promoting corneal repair.

METHODS: Totally 79 hospitalized patients(90 eyes)were divided into treatment group and control group randomly. The control group was given routine treatment; the treatment group had routine treatment and still wore hydrophilic soft corneal contact lens. The alleviating corneal irritation symptoms and promoting corneal repair between two groups were compared.

RESULTS: Cornea irritation symptoms in the treatment group patients had significantly alleviated than control group, there were significant differences(H=26.801,P<0.001), it can be considered that the overall distribution of the symptoms was different between the two groups. In corneal wound healing, there were significant differences(H=7.347, P<0.05)between the two groups at one day post-operation. It can be considered that the overall distribution of the symptoms was different between the two groups at 1 day post-operation. There were significant differences(H=13.495, P<0.001)between the two groups in pterygium post-operation. There were no significant differences(H=0.006, P>0.05)between the two groups in bullous keratopathy postoperation. There were no significant differences(H=0.245, P>0.05)between the two groups in filamentous keratitis post-operation. In corneal wound healing, there were not significant differences(H=0.708, P>0.05)between the two groups at one week post-operation. It cannot be considered that the overall distribution of the symptoms was different between the two groups.

CONCLUSION: The using of therapeutic corneal contact lens not only reduces the suffering of patients with corneal diseases, but also shortens the repairing time of corneal epithelial, reduces the economic pressure of the patients, and is conducive to clinical treatment and nursing. However, for bullous keratopathy, the main cure is still penetrating corneal transplantation at present.