AIM: To observe the effect of Mecobalamin for the treatment of the patients with optic nerve injury.

METHODS: Thirty-eight(38 eyes)patients randomly received either Mecobalamin treatment 21 cases or Tolazoline treatment 17 cases. Patients were treated with Mecobalamin injection 500μg or Tolazoline 12.5mg by hemisphere injection respectively. The change of vision and visual field for the treatment of optic nerve injury was compared.

RESULTS: The effect rate was 80% in the group treated with Mecobalamin and 44% in the controlled group with tolazoline: there was a statistical significant difference between them(P<0.05).

CONCLUSION:Mecobalamin is an effective and security medicine for the treatment of optic nerve injury.