玻璃体腔注射曲安奈德减轻视网膜静脉阻塞继发的黄斑水肿
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Macular edema owing to retinal vein occlusion treated by intravitreal triamcinolone acetonide
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    摘要:

    目的:评估玻璃体腔内注射曲安奈德(triamcinolone acetonide,TA)治疗视网膜静脉阻塞(retinal vein occlusion,RVO)引起的黄斑水肿的长期安全性与有效性。

    方法:患者17例17眼出现视网膜静脉阻塞引起的黄斑水肿,接受玻璃体腔内注射2mg TA,随访1a,监测患者视力、黄斑厚度。

    结果:随访发现,15眼(88%)视力得到明显改善,从术前0.114±0.068增加到术后的0.184±0.094,差异有统计学意义(P<0.05),而中央黄斑区的厚度从术前的514.0±67.4μm减少到术后的442.0±61.5μm,差异有统计学意义(P<0.05)。术后6例患者出现短期眼压升高,并无并发性白内障,玻璃体出血,视网膜脱离以及眼内炎的发生。

    结论:玻璃体腔内注射TA能长期有效减缓RVO引起的黄斑水肿。

    Abstract:

    AIM: To assess the long-term safety and efficacy of intravitreal triamcinolone acetonide(TA)injection in the management of macular edema caused by retinal vein occlusion(RVO).

    METHODS: This prospective, interventional case series included 17 patients(17 eyes)with RVO and macular edema. They received an intravitreal injection of 2mg TA. Follow-up was for 1 year. Outcome measures were visual acuity and macular thickness measured using ocular coherence tomography(OCT).

    RESULTS: In our group, visual acuity measurements showed that 15 eyes(88%)had improved visual acuity, and mean visual acuity increased from 0.114±0.068 preoperatively to a postoperative visual acuity of 0.184±0.094(P<0.05). The central macular thickness was reduced from 514.0±67.4μm to 442.0±61.5μm(P<0.05). Six patients in the study suffered a rise in intraocular pressure(IOP)(35%)temporarily. There was no case of visually significant cataract, vitreous haemorrhage, retinal detachment, or endophthalmitis.

    CONCLUSION:Intravitreal injection of triamcinolone acetonide can effectively improve the macular edema caused by retinal vein occlusion.

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刘伟,程扬.玻璃体腔注射曲安奈德减轻视网膜静脉阻塞继发的黄斑水肿.国际眼科杂志, 2013,13(7):1406-1407.

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  • 收稿日期:2013-04-04
  • 最后修改日期:2013-06-25
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  • 在线发布日期: 2013-07-01
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