AIM: To analyze the clinical effects of topical tobramycin-dexamethasone coulentum in the treatment of meibomian gland dysfunction(MGD).

METHODS: Totally 87 MGD patients(174 eyes)were chosen from January 2012 to June 2012. All patients were divided into three groups according to medical order. Observation index was analyzed before treatment, 1 week after treatment, 4 weeks after treatment.

RESULTS: There were statistical difference in symptoms scores(SS), breakup time of tear film(BUT), corneal fluorescein staining scores(CFS), Schirmer I test(SⅠt), limbi margin scores(LMS)before treatment and 1 week,4 week after treatment among three groups by paired tests.SS and LMS at 1 week, 4 weeks after treatment in observation group were better than that in control group, there were statistical differences, and there were statistical differences in above indicators between Erythromycin eye ointment group and observation group, observation group were superior to Erythromycin eye ointment group.

CONCLUSION: Topical tobramycin-dexamethasone coulentum is effective for MGD. It can significantly improve the symptoms and signs for patients with MGD. Its effect is satisfied.