AIM:To evaluate microperimetry in treatment of acute pan-uveitis patients before and after glucocorticoid pulse therapy, and to provide evidence for the clinical application of microperimetry.

METHODS:Fifty-three patients(106 eyes)with acute pan-uveitis who came to hospital within 5 days of onset were enrolled. The data of visual acuity, best corrected visual acuity, microperimetry images, OCT and flare examination outcome were analyzed before glucocorticoid pulse therapy and 1, 3, 7d, 1 month and 3 months after the therapy. The changes in visual acuity, light sensitivity, cell value of aqueous humor and macular edema were observed.

RESULTS: In patients with acute pan-uveitis, inflammation subsided gradually after treatment. Compared with the data before corticosteroid pulse therapy, all the data after the therapy showed significant improvement(P<0.05). Patients' vision at various times after the treatment improved gradually. The thickness of neuroepithelial layer of macular retina improved from(281±61)μm before treatment to(149±43)μm after treatment with significant difference(P=0.000). Flare examination result changed from 213.9±13.8 before treatment to 18.2±2.2 after treatment with significant difference(P=0.000).

CONCLUSION:Microperimetry can reveal the changes in visual acuity and light sensitivity before and after the glucocorticoid pulse therapy in patients with acute pan-uveitis, which suggests that microperimetry can serve as an efficient way to observe the development of acute pan-uveitis and its therapeutic effects.