方法：设实验组10眼，对照组10眼，正常组20眼。实验组和对照组分别用浓度400μL/L(0.2mL)芥子气液和浓度200μL/L(0.2mL)芥子气液接触角膜4min，于1，2，3，4，5，6d； 1，2，3wk； 1，3mo行角膜白光及荧光照相，并测量角膜中央厚度。

结果：实验组的角膜上皮损伤面积1wk内由Ⅳ级减小为0级，第2，3wk； 1mo角膜上皮反复发生点片状剥脱。对照组的角膜上皮损伤面积3d内由Ⅲ级减小为0级，第2，3wk； 1mo角膜上皮仅发生针尖样的缺损。第3mo实验组和对照组角膜上皮均恢复光滑平面。角膜中央厚度第1～6d实验组明显高于对照组和正常组，差异有统计学意义(P<0.05)。第1wk～1mo实验组、对照组和正常组相比，差异无统计学意义。第3mo实验组、对照组高于正常组，但差异无统计学意义。

结论：不同浓度的芥子气液可致兔角膜上皮不同程度的损伤和角膜厚度变化，1wk内出现一过性角膜上皮层的重塑改变，1mo内完全恢复。3mo内角膜厚度基本恢复正常。

METHODS: Twenty rabbits(40 eyes)were divided into two groups randomly, the experimental group included 10 cases(10 right eyes), the control group included 10 cases(10 right eyes), and the left eyes were normal group. The corneas of the rabbits were contacted the liquid mustard gas 400μL/L(0.2mL)and 200μL/L(0.2mL)for 4min in the experimental group and the control group respectively. Then the corneal white light and photofluorography at were conducted at 1, 2, 3, 4, 5, 6d; 1, 2, 3wk; 1, 3mo and the corneal center thickness was measured respectively.

RESULTS: The area of corneal epithelium lesions in experimental group degraded from Ⅳ to 0 after 1wk. The lesions were appeared as flake sample repeatedly in 2wk, 3wk, 1mo, delayed to healing. And that area in control group degraded from Ⅲ to 0 after 1wk. The lesions were appeared as pinpoint sample in 2wk, 3wk, 1mo. The central corneal thickness of experimental group was obviously higher than that of the normal and control group in 1-6d. There was statistically significant difference between the two groups(P<0.05). In 1wk-1mo the difference of three group was not statistically significant(P>0.05). In 3mo the experimental and control group were higher than the normal group, but the difference was not statistically significant(P>0.05).

CONCLUSION: Mustard gas of different concentrations can lead different level corneal lesion and corneal thickness change. The corneal epithelium remodeling change appears within 1wk and completely recover in 1mo after the direct corneal contact. Corneal thickness gets right in 3mo.