方法：HE染色观察松弛结膜组织的组织特点，免疫组织化学方法检测20例结膜松弛症患者松弛结膜组织中Bcl-2和Bax的表达状况，并与10例正常结膜组织进行比较。

结果：松弛结膜组织鳞状上皮增生间质中有淋巴、浆细胞浸润，Bcl-2在松弛结膜组织中表达与对照组比较差别无显著性意义(P>0.05)，Bax在松弛结膜组织中表达明显增加，与对照组比较差别有显著性意义(P<0.05)，经Spearman等级相关分析(r=0.432，P>0.05)，Bcl-2与Bax阳性表达间无相关性。

结论：Bcl-2和Bax表达失衡可能在结膜松弛症的发生和发展中起着重要的作用。

METHODS: To observe the histopathological change of conjunctivochalasis by HE staining of conjunctival tissue. Immunohistochemical staining was applied to compare the expression situation of Bcl-2 and Bax in conjunctival tissue of conjunctivochalasis patient(20 samples)and the normal conjunctiva tissue(10 samples).

RESULTS: There were lymphocyte and plasmocyte infiltration in the conjunctivochalasis tissue. The expression of Bcl-2 in the conjunctivochalasis was similar with the normal conjunctiva tissue(P>0.05). The expression of Bax in the two tissues showed significant difference(P<0.05). Spearman rank correlation analysis(r=0.432, P>0.05)indicated that there was no correlation between the expression of Bcl-2 and Bax.

CONCLUSION: Unbalanced expression of Bcl-2 and Bax in conjunctival tissue may play a significant role in the occurrence and development of conjunctivochalasis.