AIM: To study the efficacy and safety of excimer laser corneal refractive surgery in treatment of hyperopic anisometropia amblyopia in adults and adolescents.

METHODS: From September 2010 to March 2013 in our hospital, 11 patients(16 eyes)with hyperopic anisometropia amblyopia were performed excimer laser corneal refractive surgery and followed up for 6mo or more, all patients age were 15 years or older. Uncorrected or best corrected visual acuity, cycloplegic refraction and stereoscopic before and after surgery were recorded. After surgery, all patients were asked if they feel visual quality was improved after surgery in everyday life and satisfied to the operation.

RESULTS: The average of 16 eyes cycloplegic refraction error(equivalent spherical)was from preoperative 5.76±1.71D reduced to postoperative 1.42±1.22D(t=13.6, P=0.00). The anisometropia of 11 patients was from preoperative 3.78±2.39D dropped to 1.14±1.50D after the operation(t=6.08, P=0.00). After surgery, the uncorrected visual acuity for distant from 0.35±0.27 rose to 0.45±0.29(t=-4.76, P<0.001); uncorrected visual acuity for near increased from 0.26±0.24 to 0.49±0.27(t=5.43, P=0.00). Preoperative worth four hole lamp examination 4 cases showed the amblyopic eye suppression. After surgery all of them were back to normal. Examined by Synoptophore, 6 cases had stereoscopisis before surgery and 10 cases after surgery. Tested by Titmus fly, the stereopsis improved significantly before and after surgery(t=-2.97, P=0.003). No obvious complications were observed during and after surgery. All patients argued of visual quality significantly improved and satisfaction to the surgery.

CONCLUSION: Excimer laser corneal refractive surgery for adults or older adolescent patients with hyperopic anisometropia amblyopiais is effective and safe, through the corrected visual acuity is improved limitedly, but the uncorrected visual acuity and stereopsis was improved obviously. This surgery improves patient visual quality and is worth to approach.