Advances in spectral-domain optical coherence tomography(SD-OCT)technology provide improved monitoring of progression and assistance in quantifying response to treatment modalities in neovascular age-related macular degeneration(NVAMD). There is little doubt that anti-vascular endothelial growth factor(anti-VEGF)drug therapy is becoming a new approach to the management of NVAMD, while long-term follow-up and necessary retreatments are the key issues to remain obtained visual acuity.SD-OCT imaging helps to identify early recurrence of choroidal neovascularization during treatment with anti-VEGF. This review discusses the present applications of the commercially available SD-OCT systems in the follow-up of after the injection of intravitreal anti-VEGF in NVAMD.