AIM:To observe the changes of tear film on the patients after laser in situ keratomileusis(LASIK)with corneal flap created by femtosecond laser with Oculus corneal topography.

METHODS:Totally 120 myopic patients(240 eyes)were collected who underwent femtosecond laser surgery LASIK from August to September 2013, and these patients can be followed up for 3mo. Tear break-up time(BUT)and tear meniscus height(TMH)with Oculus corneal topography were recorded preoperatively and postoperatively at 1wk; 1, 2 and 3mo.

RESULTS: Oculus BUT: there existed obvious differences(P=0.012, 0.000, 0.023<0.05)in 1wk, 1 and 2mo compared with the preoperative level. While no such obvious difference(P=0.236>0.05)existed in 3mo compared with the preoperative level. TMH: there existed obvious differences(P=0.025, 0.019, 0.026<0.05)in 1wk, 1 and 2mo compared with the preoperative level. No such obvious difference(P=0.375>0.05 )existed in 3mo compared with the preoperative level.

CONCLUSION: Femtosecond laser surgery affects the stability of the tear film at a certain time and a certain extent. The mechanism related to many factors. It is temporary and lighted.