AIM: To discuss the effects and security of the application of intravitreous bevacizumab(IVB)before pars plana vitrectomy(PPV)in proliferative diabetic retinopathy(PDR).

METHODS: Retrospective study of 74 patients(80 eyes)with PDR. These patients were randomly divided into two groups, some patients in PPV group and others patients in PPV+IVB group. The PPV+IVB group were treated with IVB 10d before operation. The operating time, postoperative eyesight, intraocular pressure(IOP), complications and bleeding during operation and postoperation between the two groups were observed and compared.

RESULTS: Operating time and postoperative visual acuity were significantly different between the two groups. Operating time: with an average of 108±20.6min of test group and 129±32.4min of comparison group. Postoperative visual acuity: with an average of 0.32±0.20 and 0.21±0.16, there was significantly different between the two groups(P<0.05). Three months after operation, IOP was no significantly different between the two groups with an average of 21.3±7.2mmHg and 20.6±6.7mmHg(P>0.05).

CONCLUSION:Bevacizumab can make active neovascular membranes fibrosis, reduce bleeding in the strip membranes process, so as to make the operation field clear, and can shorten the surgical time and get the better sight, no serious complications during postoperative period appeared.