方法：对我院人类免疫缺陷病毒(HIV)阳性住院患者38例64眼进行研究。根据CD4计数以及是否发生巨细胞病毒性视网膜炎(CMVR)分为3组，A组16例32眼，CD4计数<50个/μL，未发生CMVR； B组10例20眼CD4计数> 50个/μL，未发生CMVR； C组12例12眼CD4计数<50个/μL，伴有CMVR。以未感染HIV病毒的正常人10例20眼作为正常对照组，设为D组。采用光学相干断层扫描(OCT)对以黄斑为中心1mm直径范围内的视网膜厚度进行分析。

结果：A组黄斑中心区域的平均视网膜厚度是254.03±15.63μm，B组黄斑中心区域的平均视网膜厚度是263.11±17.12μm，C组黄斑中心区域的平均视网膜厚度是304.50±50.62μm，D组黄斑中心区域的平均视网膜厚度是257.64±8.54μm。各组黄斑中心的视网膜厚度比较，总体上有统计学差异(F=12.933，P=0.000)。CMVR组黄斑中心区域视网膜增厚，与各组组间比较有统计学差异(P=0.000)。

结论：CMVR可以导致黄斑部视网膜的结构和功能损伤，严重影响患者的视功能。早期通过OCT检查黄斑区形态结构，有助于了解CMVR病情的进展和预后。

METHODS: The study based on the data analysis of 38 human immunodeficiency virus(HIV)positive patients(64 eyes). According to CD4 count and whether cytomegalovirus retinitis(CMVR)happened, the patients were divided into 3 groups. Group A included 16 patients(32 eyes), in which CD4 count was <50cells/μL and CMVR did not happen. Group B included 10 patients(20 eyes), in which CD4 count was >50cells/μL and CMVR did not happen. Group C included 12 patients(12 eyes), in which CD4 count was <50cells/μL and CMVR just happened. Group D included 10 healthy people(20 eyes), as normal control group. By using optical coherence tomography(OCT), thickness of retina along with a 1mm diameter circle centered on macular was evaluated.

RESULTS: The mean foveal thicknesses in groups A, B, C and D were 254.03±15.63μm, 263.11±17.12μm, 304.50±50.62μm and 257.64±8.54μm in order. Compared with foveal thickness in each group, there were significant differences in general(F=12.933, P=0.000). The mean foveal thickness in groups CMVR increased, which was of significant difference(P=0.000), compared with other groups.

CONCLUSION: CMVR can impair the structure and function of macular, which then seriously affects the visual function of patients. It's helpful to understand the progress and prognosis of CMVR disease by observing macular structure with OCT in early time.