AIM: To study the clinical effect of the application of microscopic pterygium resection combined with different concentration of mitomycin C(MMC).

METHODS:A total of 110 cases of pterygium patients(120 eyes)were randomly divided into control group(58 eyes)and observation group(62 eyes)according to the odd and even number method. The control group adopted the pterygium resection combined 0.3mg/mL MMC, and the observation group was given pterygium resection combined 0.2mg/mL MMC. The cure rate and the recurrence rate, eyesight before and after the treatment, two groups of cornea and sclera wound healing situation, the incidence of postoperative complications were compared.

RESULTS: The cure rate and recurrence rate of the control group was 84.5% and 15.5% respectively, and the observation group was 93.6% and 6.5% respectively, the differences were statistically significant(P<0.05). There were statistical differences of vision of the two groups before and after treatment(P<0.05), and there were no statistical differences of the two groups between the two groups after treatment(P>0.05). The cornea, sclera, wound healing time of the observation group were less than the control group, and there were statistical differences between the two groups(P<0.05). The incidence of complications was 13.8% in the control group and 3.2% in observation group, with statistically significant difference(P<0.05).

CONCLUSION: The application effect of microscopic pterygium resection combined with MMC is remarkable, and the joint of 0.2mg/mL concentration of MMC is more safe and effective, and is worth popularizing in clinical application.