AIM:To investigate the effects of the MUC5AC levels and ocular function of the patients with glaucoma and cataract with combined surgery.

METHODS: Twenty-eight patients treated with glaucoma and cataract combined surgery were chosen as the observation group from December 2011 to June 2014 in our hospital, and other 28 cases of glaucoma and cataract did not undergo surgical treatment were selected as the control group, 30 healthy subjects were as healthy control group. the MUC5AC level and ocular surface score of the three subjects before surgery 1d, after 3 and 6mo were compared.

RESULTS: The NUC5AC of the two groups of patients was significantly lower than that of the healthy control group before surgery(P<0.05), the ocular function score was significantly higher than the healthy control group(P<0.05). After 1mo, the MUC5AC of the observation group were significantly lower than that of before surgery(P<0.05), after 3mo MUC5AC content gradually increased to preoperative levels, after 6mo the MUC5AC were significantly higher than before surgery(P<0.05). After 1mo, ocular function scores were significantly higher than the preoperative(P<0.05), while after 3mo, ocular function scores decreased after 6mo of ocular surface function scores were significantly lower than the preoperative(P<0.05). While the control group after 6mo, with the passage of time, the MUC5AC content gradually reduce, ocular function score increased gradually.

CONCLUSION: To treat the patients with glaucoma and cataract with combined surgery, the level of MUC5AC can temporary decrease. Ocular function score can temporary increase in, but after 3mo, it can be gradually improved.