AIM: To evaluate the meaning of using optical coherence tomography with enhanced depth imaging(OCT-EDI)to measure choroidal thickness of central serous retinopathy(CSC).

METHODS: With the retrospective case control study, 65 patients(65 eyes)with CSC and 50 healthy controls(50 eyes)with age, gender and diopter-matched were recruited in this study. OCT-EDI were used to measure the subfoveal choroidal thickness(SFCT)in CSC eyes, the fellow eyes and also the control eyes. Of which 40 of the 65 CSC patients self-cured, 14 of them were treated with photodynamic therapy(PDT), the left 11 accepted the laser photocoagulation(LP). SFCT were measured 3mo after that. Compared with the previous data, the statistical analysis was carried out.

RESULTS: The SFCT value of 65 CSC eyes, 65 fellow eyes and 50 control eyes were 436.23±89.50, 389.45±101.03 and 329.36±95.87μm, respectively. The SFCT of suffer and fellow eyes increased significantly compared to the control eyes(P=0.008 and 0.013, respectively). There was also significant difference in SFCT between the CSC eyes and the fellow eyes(P=0.021). The SFCT were significantly decreased after PDT(P=0.032), but with no significant changes after LP or self-cured(P=0.057 and 0.076, respectively).

CONCLUSION: OCT-EDI is a useful method to assess the choroidal topographic changes of CSC. The SFCT are significantly increased in the CSC eyes compared with that in the fellow eyes and the control eyes.