AIM: To study the clinical effect and influence of using mitomycin C for the treatment of normal tension glaucoma in deep sclerectomy.

METHODS: Sixty cases(60 eyes)in our treated patients with normal-tension glaucoma from December, 2011 to December, 2012 were refered to all ineffective medication or refusing drug treatment. All patients were randomly divided into two groups. Each group had 30 cases(30 eyes). Thirty cases of patients with deep sclerectomy were treated as control group, and another 30 patients were used mitomycin C treatment as the observation group on the basis of the above.

RESULTS: The average visual acuity of the patients of observation group after operation was significantly improved better than that of the control group(P<0.05). Functional filtering bleb formation and anterior chamber formation proportion of the patients of the observation group were higher than those of control group(P<0.05). After 3mo, postoperative vision field was narrowed in 1 eye(3%)of observation group and 4 eyes(17%)in control group, with statistical significance(P<0.05). After 3mo, 3 eyes' vision field of observation group(10%)became narrow, and 8 eyes(27%)in the control group(P<0.05). The postoperative Long-term recurrence rate of observation group was 7%, obviously lower than that of control group(17%)(P<0.05). The postoperative recurrence rate of the observation group after follow-up of 1a was only 3% and significantly lower than 13% of the control group(P<0.05).

CONCLUSION: Patients with normal tension glaucoma are given deep sclerectomy, combined with mitomycin C for treatment, and the effect is obvious, high safety, low incidence of postoperative complications, low recurrence rate, worthy of clinical application and promotion.