AIM: To investigate the therapeutic effects of Pranoprofen on tear dynamic abnormity induced by conjunctivochalasis(CCh).

METHODS: Seventy cases(70 eyes)whose the main symptoms was epiphora induced by CCh were divided into Ⅱ, Ⅲ and Ⅳ in 3 groups according to Zhang's grading standards, meanwhile, all the patients were treated with the eye drops of Pranoprofen for 2wk. After that, the curative effect of each group was analyzed before and after treatments according to the symptoms, dye disappearance test, bitter taste test and tear break-up time.

RESULTS: After 2wk treatment of Pranoprofen, the symptom of patients at grade Ⅰ and Ⅱ improved obviously grade Ⅲ improved more, grade Ⅳ did little. The positive rate of dye disappearance was the highest in grade Ⅱ, the second in grade Ⅲ, and the third in grade Ⅳ. There was significant difference among the 3 groups(P<0.05). The time of bitter taste test was shortened(P<0.05)and the tear break-up time was prolonged(P<0.05)in grade Ⅱ after treatment, however, the time of those in grade Ⅲ and Ⅳ had not changed than before(P>0.05).

CONCLUSION: Pranoprofen has good effects on tear dynamic abnormity induced by grade Ⅱ of cch.