AIM: To observe the efficacy of puerarin eye drops for patients with glaucoma and its influence on the optic disc parameters and antioxidant capacity.

METHODS: Sixty patients with glaucoma(113 eyes)were randomly divided into the control group(30 cases, 55 eyes). and the observation group(30 cases, 58 eyes). The patients in control group took based treatment, and those in observation group were treated by combined with puerarin eye drops. Then the disease-related visual acuity, visual field, intraocular pressure of two groups were compared, and optic disc parameters and antioxidant indexes capacity before and after treatment of two groups were also compared.

RESULTS: After 2, 6wk of treatment, the visual acuity and light sensitivity of observation group were higher than those of control group, while the intraocular pressure and visual field defect were smaller than those of control group(P<0.05); the rim area, rim volume, optic disc volume and horizontal diameter ratio cups of observation group were higher than those of control group, and the vertical diameter ratio cups was higher than that of control group(P<0.05); the levels of SOD, GSH-Px, TAC, CAT of observation group were all higher than those of control group, and the MDA was lower than that of control group(P<0.05).

CONCLUSION:Puerarin eye drops play the effect of reducing intraocular pressure and improving vision, the visual field loss and optic disc for patients with glaucoma through the inhibition of oxidative stress response of aqueous, and puerarin eye drops has positive significance in the treatment of glaucoma.