AIM: To study the effect of diclofenac sodium hydrodissection combined with nuclear rotation on preventing posterior capsular opacification after cataract phacoemulsification.

METHODS: Eighty patients(86 eyes)received cataract phacoemulsification in our hospital from January, 2013 to December, 2014 were enrolled and randomly divided into observation group and control group. The patients in observation group were received diclofenac sodium hydrodissection with nuclear rotation, and the patients in control group were received equilibrium liquid hydrodissection. Then degree of posterior capsular opacification, visual acuity and corneal endothelial cells count in two groups were compared.

RESULTS:(1)Posterior capsular opacification degree: posterior capsular opacification degree of patients in observation group were better than that of control group(Z=6.982, P<0.05);(2)Visual acuity: at 1, 2, 3 and 4wk after operation, the visual acuity of patients in observation group was higher than that in control group(0.37±0.07 vs 0.23±0.04, 0.68±0.09 vs 0.35±0.05, 0.77±0.09 vs 0.48±0.06, 0.91±0.12 vs 0.68±0.08; F=6.583, 8.983, 7.182, 5.492, P<0.05).(3)Corneal endothelial cells: at 1, 2, 3 and 4wk after operation, there were no significant difference for corneal endothelial cells count between two groups(F=1.841, 1.003, 0.077, 0.390, P>0.05).

CONCLUSION: Diclofenac sodium hydrodissection combined with nuclear rotation can effectively reduce the incidence of posterior capsular opacification and can be safely used for intraocular treament.