方法：采用随机、双盲、阳性药物平行对照方法，将78例眼烧伤患者随机分为维生素A棕榈酸酯眼用凝胶治疗组(A组，40例)，碱性成纤维细胞生长因子(bFGF)滴眼液治疗组(B 组，38例)。维生素A棕榈酸酯眼用凝胶和bFGF滴眼液均点眼4次/d， 疗程为14d，观察两组的角膜上皮修复情况、干眼检查结果、症状及体征评分等指标。

结果：维生素A棕榈酸酯眼用凝胶治疗组痊愈31例，显效5例，痊愈率为76%，有效率90%； bFGF治疗组痊愈32例，显效3例，痊愈率为84%，有效率为92%，两组之间无统计学差异(P > 0.05)，但维生素A棕榈酸酯眼用凝胶治疗组的Schirmer实验结果、泪膜破裂时间(BUT)与bFGF治疗组相比，均延长，两组之间有统计学差异(P<0.05)； 而且维生素A棕榈酸酯眼用凝胶治疗组患者的眼干、涩以及异物感的症状减轻程度明显好于bFGF治疗组，两者之间有统计学差异(P<0.05)。

结论：维生素A棕榈酸酯眼用凝胶对烧伤后早期眼表修复疗效确切、应用方便。

METHODS: Seventy-eight cases with thermal or chemical injuries to eyes were selected and divided into two groups by randomized, double-blind, positive drug parallel controlled method: group A(40 cases were treated with vitamin A palmitate eye gel)and group B \〖38 cases were treated with basic fibroblast growth factor(bFGF)\〗. The bFGF and vitamin A palmitate eye gel were used 4 times a day. The treatment course was 14d. Restoration of epithelial defect, Schirmer's test values, tear break-up time(BUT), and subjective assessment of symptoms and signs were observed on D1, D3, D5, D7, D10 and D14.

RESULTS: In group A, 31 cases were cured, 5 cases were effective, with the cure rate of 76% and efficiency 90%. In group B, 32 cases were cured, 3 cases were effective, with the cure rate of 84% and efficiency 92%. There were no significant differences between the two groups(P>0.05). However, there were significant differences on the results of Schirmer's test and BUT(P<0.05), those in group A were expanded compared with group B. Symptoms of dry eye, astringent and foreign body sensation of group A were significantly better than those of group B, there were significant differences(P<0.05).

CONCLUSION: Vitamin A palmitate eye gel is valuable and safe on early ocular surface reconstruction of the eyes suffered from thermal or chemical injuries.