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[摘要]
翼状胬肉是常见的眼表疾病之一,其确切病因和发病机制至今尚未完全清楚,目前认为其发生、发展是多种因素协同作用的结果。现有研究表明,翼状胬肉的发生与环境因素有密切关系。眼部长期遭到阳光照射及风沙、花粉、粉尘等长期慢性刺激是主要诱因。多种因素促使角膜缘屏障功能障碍,诱发各种生长因子及炎症因子,使结膜组织变性增生向角膜生长形成胬肉。我们对翼状胬肉发病机制的研究进展进行综述。
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[Abstract]
Pterygium is one of the most common ocular surface diseases. Its exact etiology and pathogenesis are not completely understood. At present, it is considered that its occurrence and development is the result of many factors.Current studies have indicated that the occurrence of pterygium is closely related to the environmental factors.Long time exposure to sunlight,dust, pollen and other long-term chronic stimulation are the main incentive factors.Various factors have caused limbal barrier dysfunction, induced the level of a variety of growth factors and inflammatory factors increased, so that the conjunctival tissue degenerate and proliferate to the cornea in the formation of pterygium. In this paper, the research progress of the pathogenesis of pterygium is reviewed.
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