[关键词]
[摘要]
近视是患病率最高的眼科疾病之一，目前对其发生发展机制的认识仍然有限。许多研究发现，生长因子与眼球发育和近视发病密切相关。一些具有生物学活性的生长因子，如转化生长因子(TGF)、成纤维细胞生长因子(FGF)、表皮生长因子(EGF)等分别具有影响巩膜厚度变化和调控近视发生发展等功能，在近视发病过程中起着不可忽略的作用，本文将对此进行综述。
[Key word]
[Abstract]
Myopia is one of the most popular eye diseases all over the world. The development of the current understanding of its mechanism is still limited. Many studies indicated that the growth factors closely related to eye development and myopia. Some growth factors with biological activity, such as transforming growth factor(TGF), fibroblast growth factor(FGF)and epidermal growth factor(EGF), have an impact on scleral thickness variation, the regulation of the development of myopia and so on, which plays a non-negligible role in the pathogenesis of myopia. In this paper, the function of various growth factors in myopia will be reviewed.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.81303031,81173440); 国家科技支撑计划项目(No.2015BAI04B04); 卫生行业科研专项(No.201302015); 山东省科技发展计划(No.2014GGH219004)
