方法：选取2010-03/2014-03我院眼科经眼底血管造影检查确诊为糖尿病性黄斑水肿的患者30例48眼为观察组(其中局限性水肿18眼，弥漫性水肿24眼，囊样水肿6眼)，选取视力0.8以上，经裂隙灯显微镜检查均未发现异常，全身情况无异常者15例30眼为对照组，两组研究对象均行多焦视网膜电图检查，并对其结果进行统计学分析。

结果：糖尿病性黄斑水肿组多焦视网膜电图中心凹、黄斑区、黄斑外区a、 b波的振幅密度与对照组相比均差异存在统计学意义(P<0.01)； 中心凹处观察组和对照组a波的振幅密度分别为25.2±10.48、37.93±7.19nv/deg²，b波的振幅密度分别为77.16±27.97、113.42±11.79nv/deg²； 黄斑区观察组和对照组a波的振幅密度分别为14.27±4.99、27.42±2.86nv/deg²，b波的振幅密度分别为43.14±14.77、69.99±10.07 nv/deg² ； 黄斑外区观察组和对照组a波的振幅密度分别为7.82±2.79、11.46±1.54nv/deg²，b波的振幅密度分别为19.85±6.5、31.56±6.0nv/deg²。 中心凹处、黄斑区及黄斑外区多焦视网膜电图a、b波振幅密度在局限性黄斑水肿组与弥漫性黄斑水肿组和囊样黄斑水肿组间均存在统计学意义(P<0.01)。

结论：糖尿病性黄斑水肿的多焦视网膜表现为a、 b波振幅密度下降，潜伏期延长，振幅密度比潜伏期敏感。

METHODS: Thirty cases(48 eyes, 18 eyes of local macular edema, 24 eyes of diffuse macular edema and 6 eyes of cystoid macular edema)and fifteen normal cases(30 eyes)were enrolled in the study. Multifocal electroretinogram(mfERG)system(version 3.15)was used and the recordings were evaluated.

RESULTS: Compared with the control group, a-wave and b-wave amplitude densities at the fovea, the macula and paramacular of diabetic macular edema(DME)retina were attenuated(P<0.01). The amplitude densities of a-wave at the fovea of two groups were 25.2±10.48 nv/deg² and 37.93±7.19 nv/deg². The amplitude densities of b-wave at the fovea of two groups were 77.16±27.97nv/deg² and 113.42±11.79nv/deg². The amplitude densities of a-wave at the macula of two groups were 14.27±4.99 nv/deg² and 27.42±2.86 nv/deg². The amplitude densities of b-wave at the macula of two groups were 43.14±14.77nv/deg² and 69.99±10.07 nv/deg². The amplitude densities of a-wave at paramacular of two groups were 7.82±2.79nv/deg² and 11.46±1.54nv/deg². The amplitude densities of b-wave at paramacular of two groups were 19.85±6.5nv/deg² and 31.56±6.0nv/deg². There were significant difference in a-ware amplitude density and b-ware amplitude density among three groups(local macular edema, diffuse macular edema and cystoid macular edema)(P<0.01). There were no significant differences in a-ware latency and b-ware latency among three groups(P>0.05).

CONCLUSION: The amplitude densities of a-wave and b-wave of DME retina are attenuated. The latency of a-wave and b-wave are longer. The amplitude densities are more sensitive than the latency.