AIM:To evaluate the operative effect and time effectiveness of the conventional surgery versus retrograde gas injection under nasal endoscope combined 5-Fluorouracil for lacrimal canalicular rupture.

METHODS: A total of 67 patients(67 eyes)with lower lacrimal canalicular rupture who received surgical treatment by Department of Ophthalmology in Qinhuangdao Haigang Hospital were consecutively recruited between Jan. 2009 and Dec. 2015. They were randomly divided into Group A or Group B. Group A(33 patients, 33 eyes)were treated by conventional surgery, and Group B(34 patients, 34 eyes)were treated by retrograde gas injection under nasal endoscope combined 5-Fluorouracil. Time for finding out the cute end of the lower lacrimal canaliculus and postoperative effect were recorded. Comparisons between the two groups were done with Independent sample t-test and Mann-Whitney Rank sum test.

RESULTS: Time for finding out the cute end of the lower lacrimal canaliculus of Group A was(44.42±10.66)min, and the time of Group B was(30.06±6.21)min. There was significant difference between the two groups(t=6.72, P<0.05). Lacrimal ducts flush was done at the 6mo after the survey, Group B had better effect than Group A, the difference between the two groups were significant(Z=2.47,P<0.05).

CONCLUSION: Compared with conventional surgery, retrograde gas injection under nasal endoscope combined 5-Fluorouracil for lacrimal canalicular rupture can make the operation time shorter and has better effect.