AIM: To discuss the prognosis effects of vascular endothelial growth factor(VEGF)inhibitors combined with laser therapy in patients with diabetic retinopathy.

METHODS: Totally 120 patients(129 eyes)with diabetic retinopathy were selected from September 2014 to December 2015 in our Hospital. According to the random distribution, all patients were divided into inhibitor-laser group(60 case with 65 eyes)and laser group(60 case with 64 eyes). The laser group was treated with conventional laser treatments. Inhibitor-laser group patients were given VEGF inhibitors treatment besides laser. The international standard was used to charted the visual acuity and enzyme-linked immunosorbent(ELISA)was used to detect the plasma VEGF levels. All patients were followed up for 6mo, analyzed before and after the treatment for curative effect, the lesion center concave thickness(CMT), retinal neovascularization leakage area(RNV), plasma VEGF levels and adverse reactions, and the best corrected visual acuity(BCVA)before and 1, 3, 6mo after treatment.

RESULTS: Efficient rate of inhibitor-laser group was obviously higher than that of the laser group, with statistical difference(P<0.05). CMT, RNV, plasma VEGF level of inhibitor-laser group after treatment were lower than those of laser group, with statistically significant(P<0.05). BCVA at 1, 3 and 6mo after treatment in inhibitor-laser group were obviously higher than those of laser group, with statistical difference(P<0.05). Incidence of adverse reactions of the two groups were basically the same, there was no significant difference(P>0.05).

CONCLUSION: VEGF inhibitors combined with laser therapy can effectively improve the curative effect of patients with diabetic retinopathy. It can effectively improve the retinal thickness and leakage of new blood vessels, and the patient's vision, with good security.