AIM: To evaluate the condition of Meibomian gland in different age groups patients with dry eye.

METHODS: There were divided into A to H groups according to age that 301 patients(598 eyes)with dry eye in our hospital of November 2015 to April 2016, a total of eight groups. We evaluated the condition of Meibomian gland of them through the OCULUS Keratograph, including the loss of the Meibomian gland, the shape of the Meibomian gland, eyelid ester and obstructed or not of the Meibomian gland orifices, etc.

RESULTS: There had lost of the Meibomian gland of all patients with dry eye in this study, the differences between the eight groups were statistically significant(χ²=336, P<0.05).The number of Meibomian gland of group A had no loss. The differences between the B～H groups were statistically significant(F=36.4357,P<0.05). Glands shape had become thin when the age was more than forty, getting worse as the growth of the age gradually. The differences eyelid ester and obstructed or not of the Meibomian gland orifices between the A～H groups were not statistically significant.

CONCLUSION: The OCULUS Keratograph can provide the objective and precise condition of Meibomian gland in each group of patients with dry eye for us, and the change rule of quantitative results. it can provide the diagnosing judgment for the patients of dry eye, and provide methods for clinical treatment.