AIM: To investigate the efficacy of intraoperative anterior chamber paracentesis on early stage intraocular pressure change after intravitreal injection of Conbercept.

METHODS: A prospective,randomized-controlled clinical trial was conducted on 30 eyes of 30 patients underwent intravitreal injection of Conbercept. The patients were randomly divided into Group A(15 patients with 22 treatments)and Group B(15 patients with 23 treatments)according to whether to applying anterior chamber paracentesis. IOP was measured before injection and 2, 30, 60min, 1d and 1wk after the injection with AccuPen tonometer.

RESULTS: Compared with preoperative intraocular pressure, there was no significant change in IOP of Group A(applying anterior chamber paracentesis)at any time we observed(P>0.05); while the IOP of Group B significantly increased at 2min after injection(42.4±9.3mmHg)with significant difference compared to Group A(P<0.05), and then the IOP dropped to normal(17.4±5.0mmHg)within 30min without significant difference compared to Group A(P>0.05).

CONCLUSION: Intraoperative anterior chamber paracentesis during intravitreal Conbercept can effectively control the early stage intraocular pressure raise after the injection.