AIM: To evaluate the therapeutic efficacy and safety of heavy silicone oil(HSO), Densiron 68, was used as internal tamponade to treat complex vitreoretinopathy.

METHODS: A retrospective study of 30 patients(30 eyes)who underwent vitrectomy and HSO tamponade for complex retinal detachment between January 2015 and January 2016. The best corrected visual acuity(BCVA), intraocular pressure(IOP), retinal reattachment and complications after surgery were observed.

RESULTS: There were statistical significances in both the BCVA difference between pre-operation and HSO tamponade, and the BCVA difference between pre-operation and the removal of HSO for 3mo(z=-2.198, P=0.028; z=-2.682, P=0.007). The average intraocular pressure of HSO tamponade group was 20.233±8.007mmHg, and the average intraocular pressure of pre-operation group was 16.067±4.025mmHg, showing significant difference(t=-2.913, P=0.005). Between the pre-operation group and the HSO removed group 14.933±3.423mmHg, there was no significant statistical difference in the analysis of IOP(t=2.635, P=0.430). Anatomical success was achieved in 90% of cases after the removal of HSO. Most common complications were cataract formation and oil emulsification.

CONCLUSION: Densiron-68 is a safe and effective tamponade material for the treatment of complex vitreoretinopathy. However, most common complications are cataract formation and oil emulsification. So clinicians should strictly handle indications and usage during the clinical applications.