AIM: To analyzed the effect of keratoconjunctivitis sicca treated by different medicines after phacoemulsification in patients with diabetes.

METHODS: Totally 78 diabetic patients 78 eyes with keratoconjunctivitis sicca(KCS)after phacoemulsification from March 2015 to March 2016 were selected and divided into two groups using random number table. In Group A, 39 eyes were treated with pranoprofen eye drops + artificial tears + Qiming granules. In Group B, 39 eyes were treated with pranoprofen eye drops + artificial tears. the two groups were observed for clinical symptoms, tear film break up time(BUT), corneal fluorescein staining and adverse reaction and so on before and after treatment.

RESULTS: Total effective rate of Group A was 97%, significantly higher than that of Group B(64%)(P<0.05). After treatment, symptoms and signs scores of the two groups were significantly lower, BUT were significantly prolonged. At 1, 2wk and 1mo after treatment, symptoms and signs scores of Group A were significantly lower the BUT was longer than those of Group B(P<0.05). Corneal fluorescein staining of Group A at 2wk was lower than that of Group B(P<0.05).

CONCLUSION: The combined therapy, pranoprofen eye drops + artificial tears + Qiming granules, is able to quickly and effectively improve the clinical symptoms and signs, with no serious adverse reactions for keratoconjunctivitis sicca after phacoemulsification in patients with diabetes.