方法：随机数字法将72例72眼行白内障超声乳化术的患者分为观察组与对照组，观察组术后给予小牛血去蛋白提取物滴眼液治疗，对照组则行重组人表皮生长因子滴眼液干预，比较两组术后不同时间点角膜水肿程度、自觉症状评分、角膜内皮细胞计数、角膜厚度变化及术后视力恢复情况。

结果：与术后1d比较，两组术后7d角膜水肿程度均显著改善，差异有统计学意义(P<0.001)，两组术后7d角膜水肿程度、视力检查结果比较差异均无统计学意义(均P>0.05)； 与术后1d比较，两组术后7d自觉症状评分均显著下降，差异有统计学意义(P<0.001)，观察组术后7d自觉症状评分均显著优于对照组，差异有统计学意义(P<0.05)； 与术前相比，观察组术后7d角膜厚度无统计学差异(P>0.05)，对照组较术前相比，有统计学差异(P<0.001)，且观察组角膜厚度明显小于对照组，差异有统计学意义(P<0.001)。观察组术后1mo角膜内皮细胞计数显著大于对照组，差异有统计学意义(P<0.001)。

结论：重组人表皮生长因子滴眼液与小牛血去蛋白提取物滴眼液均能明显改善白内障超声乳化术后角膜水肿症状及患者视力，但后者相比前者在修复患者术后角膜内皮细胞损伤方面有明显优势。

METHODS:Totally 72 cases(72 eyes)of patients undergoing phacoemulsification were selected and divided into the observation group and the control group by random number table method. After surgery, the observation group were treated with deproteinized calf blood extract eye drops while the control group were treated with recombinant human epidermal growth factor eye drops. The degree of corneal edema, subjective symptom score, corneal endothelium count, changes of corneal thickness and postoperative visual acuity recovery were compared between the two groups at different time points after surgery.

RESULTS:Corneal edema in the two groups was significantly milder at 1wk after surgery than that on the 1^st day after surgery(P<0.001). There was no significant difference in the degree of corneal edema and test results of visual acuity between the two groups at 1wk after surgery(P>0.05). Compared with 1d after surgery, the subjective symptom score and corneal thickness of the two groups significantly decreased on the 7^th day after surgery(P<0.05). At 7d after surgery, the above indexes were significantly better in the observation group than the control group(P<0.05). At 1mo after surgery, the corneal endothelium count was significantly larger in the observation group than the control group(P<0.001).

CONCLUSION:Both of recombinant human epidermal growth factor eye drops and deproteinized calf blood extract eye drops can significantly relieve corneal edema and improve visual acuity of patients after phacoemulsification. However, the latter has obvious advantages over the former in the repair of corneal endothelial cell injury after surgery.