The normal growth of blood vessels is the result of dynamic balance of angiogenic factor and inhibitory factor in vascular tissue. However, when the balance is broken, the growth of new blood vessels will be induced. Endogenous angiogenesis inhibitory factor, is a group of negative feedback molecules produced by the body itself that inhibit angiogenesis. Its function of inhibiting angiogenesis is mainly realized by promoting the binding of angiogenic factor to its receptor, or its downstream angiogenesis signal, or promoting vascular endothelial apoptosis. The study of angiogenesis inhibitory factor has potential clinical significance for the prevention and treatment of retinal neovascularization. Recent studies on retinal neovascularization inhibitory factor are reviewed in this paper.